Metoclopramide API Manufacturers and Suppliers in India
Metoclopramide API
Metoclopramide is used to treat the symptoms of slow stomach emptying (gastroparesis) in patients with diabetes. It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite
1. Metoclopramide Hydrochloride (IP / BP/ Ph.Eur / USP)
Metoclopramide HCl Description
Generic Name Metoclopramide HCl
Chemical Name : 4-Amino-5-chloro-N-[2-(diethylamino) ethyl]-2-methoxy-, monohydrochloride, monohydrate
Molecular weight: 336.3 g/mol
Molecular formula: C14H22CIN3O4S-HCIH2O
Category: Anti- Emetic
Therapeutic use: Relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite
Form: Crystalline powder or crystals
Color: White or almost white
Size of package: As per requirement
Storage: Store protected from light
Synonyms: MCP HCl, 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride
Solubility: Very soluble in water, freely soluble in ethanol (96%), sparingly soluble in methylene chloride
2.Metoclopramide Base (Ph.Eur / BP)
Metoclopramide Base Description
Generic Name Metoclopramide Base
Chemical Name : 4-Amino-5-chloro-N-[2-(diethylamino) ethyl]-2-methoxybenzamide
Molecular weight: 299.8 g/mol
Molecular formula: C14H22CIN3O4
Category: Anti- Emetic
Therapeutic use: Relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite
Form: Fine powder
Color: White or almost white
Size of package: As per requirement
Storage: Store protected from light in a tightly closed container
Synonyms: MCP Base, 4-amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide
Solubility: Practically insoluble in water, sparingly or slightly soluble in ethanol (96%), slightly soluble in methylene chloride
Metoclopramide API Specification
- ☐ Assay: 99.0% to 101.0% w/w (anhydrous substance)
- ☐ Total impurities: Maximum 0.2%
- ☐ Unspecified impurities: Maximum 0.1%
Quality Standards and Manufacturing Excellence of Bio Synth
Bio-Synth operates with an unwavering commitment to quality. Our manufacturing processes integrate
- ☐ WHO-GMP (Good Manufacturing Practices) compliance
- ☐ ISO 9000:2015 certification
- ☐ Adherence to ICH guidelines and pharmacopeia standards
Applications of Metoclopramide API
☐ Metoclopramide is a medication used for stomach and esophageal problems.
☐ It is commonly used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying, and to help with gastroesophageal reflux disease.
☐ It is also used to treat migraine headaches.
Therapeutic Uses and Indications
Metoclopramide is used to treat the symptoms of slow stomach emptying (gastroparesis) in patients with diabetes. It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite. Metoclopramide is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD). GERD is esophageal irritation from the backward flow of gastric acid into the esophagus.
How Metoclopramide API Works (Mechanism of Action)
The antiemetic action of metoclopramide is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone in the central nervous system this action prevents nausea and vomiting triggered by most stimuli. At higher doses, 5-HT3 antagonist activity may also contribute to the antiemetic effect
Why Choose Bio Synth For Metoclopramide API
Bio-Synth adheres to stringent quality protocols to ensure that each batch of Metoclopramide meets comprehensive global quality standards. Our robust quality control practices confirm the purity, potency, and safety of our products, ensuring reliable therapeutic results. We manufacture Metoclopramide HCl BP and Metoclopramide Base in our 120kL WHO-GMP, ISO certified facility with a capacity of 1.5 MT/month. Bio-synth has been manufacturing Metoclopramide for almost three decades and is the clear market leader catering to international and domestic markets.
Advantages and Key Features of Metoclopramide API
☐ Metoclopramide does not increase gastric acid secretion.
☐ It is available in the oral tablet form or in solution, and can also be administered through the intravenous route
Metoclopramide API Suppliers & Manufacturers in India
Bio-synth has been one of the leading Metoclopramide manufacturers in India for almost 30 years. We manufacture all intermediates of Metoclopramide in-house, ensuring superior quality, lead times and competitive pricing. We have been supplying Metoclopramide to leading Indian pharmaceutical companies and have also recently registered the product with China CDE
Metoclopramide API Price in India
Bio Synth is a reputable supplier of pharmaceutical APIs and intermediates, including Metoclopramide API, widely used for stomach and esophageal problems. Bio-Synth offers Metoclopramide API at highly competitive prices tailored to your specific requirements. We ensure the best value while maintaining the highest quality standards. For detailed pricing and further inquiries, please reach out to us directly, and our team will be happy to assist you.
Frequently Asked Questions
We are listening.
We believe that the heart of dialogue is listening. Please write in your queries and we will get back to you.
☐ Metoclopramide is a medication used for stomach and esophageal problems.
☐ It is used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying and to help with gastroesophageal reflux disease.
☐ It is also used to treat migraine headaches
Bio-synth has been one of the leading Metoclopramide manufacturers in India for almost 30 years. We manufacture all intermediates of Metoclopramide in-house, ensuring superior quality, lead times and competitive pricing.
Our facilities are equipped with cutting-edge technology and maintain strict adherence to GLP (Good Laboratory Practices), GDP (Good Documentation Practices), and cGMP (Current Good Manufacturing Practices). This results in consistent product quality, reinforcing Bio-Synth’s reputation for excellence.
To place an order for Metoclopramide API, contact Bio-Synth through the provided customer service details or fill out the contact form for sample requests and further information. We are one of the leading Metoclopramide API manufacturers in India and ensure timely delivery to meet your needs.
Bio-synth is one of the first and leading manufacturers of Metoclopramide, for 30 years now
Bio-Synth offers Metoclopramide API at highly competitive prices tailored to your specific requirements. We ensure the best value while maintaining the highest quality standards. For detailed pricing and further inquiries, please reach out to us directly, and our team will be happy to assist you.
Metoclopramide HCl is very soluble in water while Metoclopramide Base is practically insoluble in water
No, Metoclopramide Base and Metoclopramide HCl are different products with different structures, composition and specifications.
☐ The structure of Metoclopramide consists of a benzamide core with a 4-amino-5-chloro substitution on the benzene ring and a diethylaminoethyl side chain.
☐ The structure of Metoclopramide API includes two forms: Hydrochloride and Base.
☐ Structure of Metoclopramide Hydrochloride (IP / BP/ Ph.Eur / USP)
☐ Metoclopramide Base (Ph.Eur / BP)
Yes, Metoclopramide is an anti-emetic. It is commonly used to prevent depression and inflammation and is treated with various medications, surgery, gastrointestinal disorders etc. It works by increasing gastrointestinal muscles and blocking dopamine receptors in the midbrain causing inflammation.
