Bumetanide API Manufacturers And Suppliers in India

Bumetanide is a sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Bumetanide has USFDA approval for managing various edematous conditions secondary to cardiac failure with or without ascites or hepatic/renal disease, including nephrotic syndrome. It may also be indicated for refractory edema resistant to other loop diuretics. Bumetanide may be used alone or in conjunction with other antihypertensive agents in treating hypertension, although this is not an FDA-approved indication. Treating acute hypercalcemia is also an off-label indication for the drug.

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Product Description

Product Description

Generic Name: Bumetanide API

Chemical Name : 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid

CAS Number : 28395-03-1

Molecular weight:364.42 g/mol

Molecular formula: C17H20N2O5S

Category: Loop diuretic

Therapeutic use: Used to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions

Form: Powder

Color: White or almost white

Size of package: As per requirement

Solubility: Practically insoluble in water, soluble in acetone and in ethanol (96%), slightly soluble in methylene chloride

Bumetanide API Specification

  • ☐ Total impurities: Not more than 0.2% w/w
  • ☐ Any unspecified impurity: Not more than 0.1% w/w
  • ☐ Assay by HPLC: Not less than 98% w/w and not more than 102% w/w

Bumetanide API Manufacturers & Suppliers in India

Bio Synth is a trusted manufacturer and supplier of Bumetanide API in India, known for delivering high-quality pharmaceutical ingredients. With state-of-the-art manufacturing facilities and adherence to stringent regulatory standards such as USFDA, WHO-GMP, and EU-GMP, Bio Synth ensures consistency and reliability in its products. The company specializes in producing APIs with a focus on innovation, quality assurance, and timely delivery. Catering to both domestic and international markets, Bio Synth provides cost-effective solutions without compromising on quality. With a commitment to excellence, Bio Synth is a preferred partner for pharmaceutical companies seeking dependable Bumetanide API suppliers.

Quality Standards and Manufacturing Excellence of Bio-Synth

Bio-Synth operates with an unwavering commitment to quality. Our manufacturing processes integrate

  • ☐ WHO-GMP (Good Manufacturing Practices) compliance
  • ☐ ISO 9000:2015 certification
  • ☐ Adherence to ICH guidelines and pharmacopeia standards

Our facilities are equipped with cutting-edge technology and maintain strict adherence to GLP (Good Laboratory Practices), GDP (Good Documentation Practices), and cGMP (Current Good Manufacturing Practices). This results in consistent product quality, reinforcing Bio-Synth’s reputation for excellence.

Applications of Bumetanide API

Bumetanide has USFDA approval for managing various edematous conditions secondary to cardiac failure with or without ascites or hepatic/renal disease, including nephrotic syndrome. It may also be indicated for refractory edema resistant to other loop diuretics. Bumetanide may be used alone or in conjunction with other antihypertensive agents in treating hypertension, although this is not an FDA-approved indication. Treating acute hypercalcemia is also an off-label indication for the drug.

Therapeutic Uses and Indications of Bumetanide API

Bumetanide is a potent loop diuretic primarily used for the treatment of edema associated with conditions such as congestive heart failure, hepatic disease, and renal disorders, including nephrotic syndrome. By promoting significant fluid excretion, it effectively alleviates swelling and associated symptoms. Additionally, Bumetanide aids in the management of hypertension by eliminating excess fluid, thereby reducing blood volume and vascular resistance. It is particularly beneficial in patients who are unresponsive to other diuretics due to its high potency and rapid onset of action, ensuring improved symptom relief and enhanced patient outcomes.

How Bumetanide API Works (Mechanism of Action)

Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.

Why Choose Bio-Synth for Bumetanide API

Bio-Synth adheres to stringent quality protocols to ensure that each batch of Bumetanide API meets comprehensive global quality standards. Our robust quality control practices confirm the purity, potency, and safety of our products, ensuring reliable therapeutic results. We manufacture Carglumic acid API in our 60kL WHO-GMP, ISO certified facility with a capacity of 200 kg/month.

Advantages And Key Features of Bumetanide API

It is often used in patients in whom high doses of furosemide are ineffective. There is however no reason not to use bumetanide as a first choice drug. The main difference between the two substances is in bioavailability. Bumetanide has more predictable pharmacokinetic properties as well as clinical effect. In patients with normal renal function, bumetanide is 40 times more effective than furosemide.

Bio Synth: Bumetanide API Suppliers in India

Bio-synth is one of the leading API manufacturers in India that has included Bumetanide API in its product portfolio. Bio-synth manufactures all intermediates of Bumetanide API in-house, thereby offering the best quality, price and lead time.

Bumetanide API Price in India

Bio Synth is a reputable supplier of pharmaceutical APIs and intermediates, including Bumetanide API, used to treat edema. Bio-Synth offers Bumetanide API at highly competitive prices tailored to your specific requirements. We ensure the best value while maintaining the highest quality standards. For detailed pricing and further inquiries, please reach out to us directly, and our team will be happy to assist you.

Frequently Asked Questions

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    Bumetanide API is the key component in the sulfamyl diuretic drug used to treat edema associated with congestive heart failure, liver cirrhosis, and renal disorders

    Bumetanide is used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome.

    Bio-Synth offers premium-quality Bumetanide API at competitive prices, tailored to meet your specific requirements. By handling all production stages internally, we maintain strict control over quality while optimizing pricing. For accurate pricing and to discuss your specific needs, we encourage you to reach out with your inquiry. Our team is dedicated to providing timely responses and ensuring your complete satisfaction.

    Bio-synth is one of the top manufacturers of APIs in India. We also manufacture Bumetanide API, offering top quality, competitive prices, and short lead time.

    The chemical composition of Bumetanide API is C17H20N2O5S, which stands for 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid

    Yes, Bumetanide API is available for purchase in India. Bio-synth is one of the leading manufacturers and suppliers of API products. Please reach out via the enquiry form with your requirement, and we will be happy to assist you.

    Bio-Synth has almost 8 decades of experience manufacturing high-quality APIs, with Bumetanide API as one of the key products in its product portfolio, making Bio-Synth one of the trusted manufacturers in India.

    Bio-Synth offers high-quality Carglumic acid API that meets global standards like WHO-GMP and ISO 9000:2015 certification. Our rigorous quality control ensures a consistent and reliable Carglumic acid API supply, making us a top choice for Carglumic acid API suppliers in India.

    Our facilities are equipped with cutting-edge technology and maintain strict adherence to GLP (Good Laboratory Practices), GDP (Good Documentation Practices), and cGMP (Current Good Manufacturing Practices). This results in consistent product quality, reinforcing Bio-Synth’s reputation for excellence.

    To place an order for Bumetanide API, contact Bio-Synth through our customer service team or by filling out the contact form on our website. We provide comprehensive support to guide you through the order process and ensure timely delivery to meet your specific needs.