Carvedilol API Manufacturers and Suppliers in India

Carvedilol

Carvedilol API is a nonselective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients

Description

Name of the product: Carvedilol USP/IP

Chemical Name :  (2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol

Molecular weight: 406.47 g/mol

Molecular formula: C24H26N2O4

Category: Beta blocker

Therapeutic use:  To treat heart failure, left ventricular dysfunction, and hypertension

Physical Form:  Crystalline powder

Color: White or almost white crystalline

Package: As per requirement

Storage: 

☐ USP Grade: Preserve in a tight container, and store at controlled room temperature

☐ IP Grade: Store protected from light, at a temperature not exceeding 30 deg C
Synonyms: Carvedilolum

Carvedilol API Specification

USP Grade:

  1. Assay by HPLC: 98.0%-102.0% w/w (Dried substance)
  2. Total impurities: Not more than 0.5%
  3. Any other impurity: Not more than 0.1%

IP Grade:

  1. Assay by Potentiometry: 99.0%-101.0% (Dried substance)
  2. Total impurities: Not more than 0.5%
  3. Any other impurity: Not more than 0.2%

Quality Standards and Manufacturing Excellence of Bio-Synth

Bio-Synth operates with an unwavering commitment to quality. Our manufacturing processes integrate

☐ WHO-GMP (Good Manufacturing Practices) compliance

☐ ISO 9000:2015 certification

☐ Adherence to ICH guidelines and pharmacopeia standards

Our facilities are equipped with cutting-edge technology and maintain strict adherence to GLP (Good Laboratory Practices), GDP (Good Documentation Practices), and cGMP (Current Good Manufacturing Practices). This results in consistent product quality, reinforcing Bio-Synth’s reputation for excellence.

Applications of Carvedilol API

Carvedilol oral tablets are used to treat high blood pressure. It can also improve how well your heart works if you’ve had a heart attack or if you have heart failure.

This drug is approved to treat:

  1. Heart failure
  2. Left ventricular dysfunction (a heart function problem) after a heart attack
  3. High blood pressure

Therapeutic Uses and Indications


Carvedilol is a non-selective beta-blocker with several properties, including:

  1. Vasodilating: Carvedilol has vasodilating properties due to its alpha-1 blocking activity. It reduces peripheral vascular resistance and has a lesser effect on heart rate than other beta-blockers. 
  2. Antioxidant: Carvedilol has antioxidant properties that are greater than those of vitamin E. 
  3. Antiproliferative: Carvedilol has antiproliferative effects on smooth muscle cells. 
  4. Neutral effect on lipids and glucose: Carvedilol has a neutral effect on lipids and glucose metabolism. 
  5. Improved glycemic control: Carvedilol has better effects on glycemic control, insulin sensitivity, and lipid metabolism than other beta-blockers. 
  6. Reduced mortality: Carvedilol has been shown to reduce mortality in adults with heart failure. 
  7. Improved functional class: Carvedilol has been shown to improve functional class in adults with heart failure. 
  8. Reduced progression of disease: Carvedilol has been shown to reduce the progression of heart failure in adults.

How Carvedilol API Works (Mechanism of Action)

Carvedilol is a non-selective beta blocker that works by blocking alpha-1 and beta-1 receptors in the heart and blood vessels:

  1. Blocks alpha-1 receptors 
    Carvedilol blocks alpha-1 receptors in the blood vessels, which causes vasodilation and reduces peripheral vascular resistance. This helps blood vessels relax.
  2. Blocks beta-1 and beta-2 receptors
    Carvedilol blocks beta-1 and beta-2 receptors in the heart, which prevents reflex tachycardia and helps the heart beat more slowly. This helps the heart work better.

Why Choose Bio-Synth for Carvedilol API

With 81 years of experience manufacturing APIs and intermediates, Bio-synth supplies high-quality products in India and internationally. Bio-Synth adheres to stringent quality protocols to ensure that each batch of Carvedilol meets comprehensive global quality standards. Our robust quality control practices confirm the purity, potency, and safety of our products, ensuring reliable therapeutic results. Our 120kL WHO-GMP, ISO certified facility has a capacity to manufacture 0.5 MT of Carvedilol per month. Bio-synth manufacturers all intermediates of Carvedilol in-house, ensuring superior quality, price and delivery schedules.

Advantages and Key Features of Carvedilol API

  1. Effective in Managing Heart Failure and Hypertension: Carvedilol helps lower blood pressure and improves heart function by blocking beta and alpha receptors.
  2. Reduces Cardiovascular Complications: It helps prevent heart attacks, strokes, and arrhythmias, lowering overall cardiovascular risk.
  3. Long Duration of Action: Carvedilol provides sustained therapeutic effects, reducing the need for frequent dosing and ensuring consistent blood pressure and heart rate control.
    Carvedilol offers long-lasting benefits in managing heart failure and hypertension while reducing cardiovascular risks.

Carvedilol API Price in India

Bio Synth is a reputable supplier of pharmaceutical ingredients, including Carvedilol API, widely used in the treatment of cardiovascular conditions like hypertension and heart failure. Bio-Synth offers Carvedilol API at highly competitive prices tailored to your specific requirements. We ensure the best value while maintaining the highest quality standards. For detailed pricing and further inquiries, please reach out to us directly, and our team will be happy to assist you.

Frequently asked questions

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    Carvedilol is a nonselective beta-adrenergic antagonist used to treat mild to severe chronic hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients

    Bio-synth manufacturers USP and IP grades of Carvedilol, that meet the stringent quality requirements of global and Indian pharmacopoeia standards

    Bio-Synth stands out as a trusted Carvedilol API manufacturer in India due to its strict adherence to global standards, such as WHO-GMP and ISO 9000:2015 certifications. We focus on high-quality, reliable production, offering competitive pricing and customizable solutions. Our robust quality control and consistent supply make Bio-Synth a dependable partner for pharmaceutical companies needing top-quality Carvedilol API

    To place an order for Carvedilol API, contact Bio-Synth through the provided customer service details or fill out the contact form for sample requests and further information. We are one of the leading Carvedilol API manufacturers in India and ensure timely delivery to meet your needs.